POLR2J3

Across TCGA cell cohorts, POLR2J3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR2J3-associated genes across cancer lineages are PRORY, CXorf51A, and RPS4Y2. Each is linked with POLR2J3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2J3-to-partner and partner-to-POLR2J3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRORY grouped by POLR2J3-low versus POLR2J3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2J3→partner) and Y-score (partner→POLR2J3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRORY →	+0.536	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	CXorf51A →	+0.066	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	RPS4Y2 →	+0.080	+4.643	<.001	.008	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRORY by POLR2J3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →