POLR2I

Across TCGA patient cohorts, POLR2I mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible POLR2I-associated genes across cancer lineages are LINC01809, RNA5SP459, and MIR7976. Each is linked with POLR2I in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2I-to-partner and partner-to-POLR2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01809 grouped by POLR2I-low versus POLR2I-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2I→partner) and Y-score (partner→POLR2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01809 →	+0.253	+4.358	<.001	.001	3	2
SKCM	RNA5SP459 →	+0.294	+7.816	.001	.008	3	1
UCEC	MIR7976 →	+0.568	+3.453	.002	.009	3	1
UCEC	RPS29P32 →	+0.894	+3.599	<.001	.007	3	1
LUAD	TMOD4 →	+0.014	+7.930	<.001	.008	3	1
LUAD	OR2M7 →	+0.034	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

LINC01809 by POLR2I expression — UCEC

Explore this box plot interactively →