POLR2I

Across TCGA cell cohorts, POLR2I RNA expression is significantly associated with the go_rna of many other GO terms, with 3,421 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POLR2I-associated GO terms across cancer lineages are Spliceosomal snRNP assembly, Transcription initiation at RNA polymerase II promoter, and Free ubiquitin chain polymerization. Each is linked with POLR2I in more than 9 cancer types. Because this analysis shows association rather than direction, both POLR2I-to-partner and partner-to-POLR2I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal snRNP assembly grouped by POLR2I-low versus POLR2I-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2I→partner) and Y-score (partner→POLR2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Spliceosomal snRNP assembly →	+0.072	+0.620	.001	.003	3	10
URINARY_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.047	+0.584	.006	.003	3	10
LIVER	Free ubiquitin chain polymerization →	+0.186	+0.751	<.001	.006	3	9
BONE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.157	+0.626	.003	.008	2	10
BLOOD_Myeloma	Protein transmembrane transport →	+0.068	+1.041	.001	<.001	3	9
BONE	Malate transport →	+0.214	+0.795	.008	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,421 associations by consensus.

Spliceosomal snRNP assembly by POLR2I expression — STOMACH

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