POLR2H

Across TCGA pan-cancer cohorts, POLR2H Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POLR2H data layer compared with 30 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher POLR2H Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2H expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, ACC, and UCEC are the cancer types where POLR2H Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
UCEC	DFS	Median	All	1.000	0.625	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

POLR2H–MESO (DFS)

Open the MESO breakdown →