POLR2H

Across TCGA pan-cancer cohorts, POLR2H mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR2H data layer compared with 30 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLR2H mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2H expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where POLR2H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.700	0.926	.003	59	view →
PDAC	DFS	Tertile	II,III,IV	0.163	0.438	.003	35	view →
LUAD	OS	Median	All	0.922	0.626	.010	19	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.460	.003	18	view →
HNSC	DFS	Tertile	All	1.000	0.931	.022	4	view →
UCEC	DFS	Median	II,III,IV	0.882	0.518	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR2H–CCRCC (OS)

Open the CCRCC breakdown →