POLR2D

Across TCGA pan-cancer cohorts, POLR2D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR2D data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2D expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where POLR2D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.584	0.857	.004	24	view →
LUAD	OS	Tertile	All	1.000	0.902	.011	19	view →
PDAC	DFS	Median	All	0.834	0.691	.002	18	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	6	view →
LSCC	OS	Median	All	0.879	0.700	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLR2D–HNSC (DFS)

Open the HNSC breakdown →