POLR2D

Across TCGA patient cohorts, POLR2D protein abundance is significantly associated with the RNA expression of many other genes, with 10,088 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR2D-associated genes across cancer lineages are TFAP4, FBL, and TWNK. Each is linked with POLR2D in more than 5 cancer types. Because this analysis shows association rather than direction, both POLR2D-to-partner and partner-to-POLR2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2D versus TFAP4 in UCEC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2D→partner) and Y-score (partner→POLR2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFAP4 →	+0.493	+0.210	<.001	.001	3	6
BRCA	FBL →	+0.818	+0.294	<.001	<.001	3	5
OV	TWNK →	+0.958	+0.307	<.001	<.001	3	5
LSCC	GTPBP3 →	+0.655	+0.222	.001	<.001	3	5
UCEC	DKC1 →	+0.669	+0.220	.001	.003	3	5
LSCC	TAF5 →	+0.580	+0.253	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,088 associations by consensus.

POLR2D vs TFAP4 — UCEC

Explore this scatter interactively →