POLR2D

Across TCGA patient cohorts, POLR2D protein abundance is significantly associated with the protein abundance of many other proteins, with 23,663 significant associations in total. GBM shows the largest number of these associations.

The most reproducible POLR2D-associated proteins across cancer lineages are SMNDC1, PPP1R8, and POLR2C. Each is linked with POLR2D in more than 9 cancer types. Because this analysis shows association rather than direction, both POLR2D-to-partner and partner-to-POLR2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR2D versus SMNDC1 in OV, with a Pearson correlation of 0.51.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2D→partner) and Y-score (partner→POLR2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMNDC1 →	+0.312	+0.203	<.001	.001	3	10
PDAC	PPP1R8 →	+0.297	+0.349	<.001	<.001	3	10
PDAC	POLR2C →	+0.267	+0.315	<.001	.002	3	9
GBM	CSTF1 →	+0.310	+0.277	<.001	<.001	3	9
COAD	CWC15 →	+0.304	+0.267	<.001	<.001	3	9
GBM	DDX17 →	+0.301	+0.284	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,663 associations by consensus.

POLR2D vs SMNDC1 — OV

Explore this scatter interactively →