POLR2D

Across TCGA patient cohorts, POLR2D mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2D-associated genes across cancer lineages are Class-switched memory B-cells, Erythrocytes, and Astrocytes. Each is linked with POLR2D in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2D-to-partner and partner-to-POLR2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Class-switched memory B-cells grouped by POLR2D-low versus POLR2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2D→partner) and Y-score (partner→POLR2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Class-switched memory B-cells →	-0.056	-3.044	.031	.014	2	1
UCEC	Erythrocytes →	+0.036	+2.700	.001	.006	2	1
UCEC	Astrocytes →	-0.044	-3.130	.034	.012	2	1
UCEC	Endothelial cells →	-0.051	-2.657	.002	.006	1	1
UCEC	lymphatic Endothelial cells →	-0.030	-2.646	.004	.006	1	1
UCEC	mv Endothelial cells →	-0.032	-2.689	.002	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Class-switched memory B-cells by POLR2D expression — UCEC

Explore this box plot interactively →