POLR2D

Across TCGA cell cohorts, POLR2D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,997 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2D-associated GO terms across cancer lineages are Positive regulation of cell cycle process, Positive regulation of cytokinesis, and Positive regulation of cell cycle. Each is linked with POLR2D in more than 17 cancer types. Because this analysis shows association rather than direction, both POLR2D-to-partner and partner-to-POLR2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle process grouped by POLR2D-low versus POLR2D-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2D→partner) and Y-score (partner→POLR2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of cell cycle process →	+0.082	+0.847	.001	.004	3	18
PANCREAS	Positive regulation of cytokinesis →	+0.134	+0.824	<.001	.001	3	17
KIDNEY	Positive regulation of cell cycle →	+0.084	+0.839	<.001	<.001	3	17
BONE	DNA replication initiation →	+0.191	+0.875	<.001	<.001	3	17
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.210	+0.762	<.001	<.001	3	17
SKIN	Microtubule cytoskeleton organization involved in mitosis →	+0.123	+0.735	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,997 associations by consensus.

Positive regulation of cell cycle process by POLR2D expression — BREAST

Explore this box plot interactively →