POLR2B

Across TCGA pan-cancer cohorts, POLR2B Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated POLR2B data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POLR2B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR2B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, OV, and SCLC are the cancer types where POLR2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.957	0.610	.002	20	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
SCLC	OS	Median	All	0.205	0.713	<.001	12	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	12	view →
ESCA	OS	Median	All	0.181	0.704	<.001	12	view →
LUSC	OS	Median	All	0.296	0.664	.004	10	view →
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
PRAD	DFS	Median	All	0.722	0.935	.018	6	view →
SKCM	OS	Median	All	0.621	0.870	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

POLR2B–UCEC (DFS)

Open the UCEC breakdown →