POLR2B

Across TCGA pan-cancer cohorts, POLR2B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR2B data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLR2B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR2B expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where POLR2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.716	0.253	.006	19	view →
LSCC	DFS	Median	All	0.969	0.909	.006	17	view →
HNSC	OS	Tertile	All	0.769	0.903	.005	10	view →
UCEC	DFS	Median	II,III,IV	0.550	0.857	.033	4	view →
CCRCC	OS	Median	All	0.741	1.000	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLR2B–LUAD (DFS)

Open the LUAD breakdown →