POLR2B

Across TCGA pan-cancer cohorts, POLR2B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of POLR2B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where POLR2B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2B is over-expressed in tumor.

LSCC, COAD, and HNSC are the cancer types where POLR2B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.292	<.001	9	view →
COAD	Male	III,IV	+0.223	<.001	9	view →
HNSC	Male	II,III,IV	+0.225	<.001	8	view →
LUAD	Male	All	+0.188	<.001	7	view →
CCRCC	Male	III,IV	+0.126	<.001	6	view →
OV	All	All	+0.216	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

POLR2B–LSCC

Open the LSCC breakdown →