POLR2B

Across TCGA patient cohorts, POLR2B mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2B-associated genes across cancer lineages are 4E-BP1, ATM, and eIF4E. Each is linked with POLR2B in more than 3 cancer types. Because this analysis shows association rather than direction, both POLR2B-to-partner and partner-to-POLR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by POLR2B-low versus POLR2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2B→partner) and Y-score (partner→POLR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.300	+3.999	<.001	<.001	3	4
UCEC	ATM →	-0.404	-1.115	.002	.026	3	3
COAD	eIF4E →	+0.192	+3.012	.029	.018	3	2
UCEC	FOXO3a_pS318_S321 →	-0.077	-1.279	.033	.021	3	2
UCEC	INPP4B →	-0.282	-2.321	.002	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.141	-1.847	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

4E-BP1 by POLR2B expression — UCEC

Explore this box plot interactively →