POLR2B

Across TCGA cell cohorts, POLR2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,987 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2B-associated GO terms across cancer lineages are Protein K11-linked ubiquitination, Ribosome localization, and Ribosomal subunit export from nucleus. Each is linked with POLR2B in more than 13 cancer types. Because this analysis shows association rather than direction, both POLR2B-to-partner and partner-to-POLR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K11-linked ubiquitination grouped by POLR2B-low versus POLR2B-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2B→partner) and Y-score (partner→POLR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Protein K11-linked ubiquitination →	+0.065	+0.567	.001	.001	3	14
BLOOD_Leukemia	Ribosome localization →	+0.101	+0.856	<.001	<.001	3	14
BLOOD_Leukemia	Ribosomal subunit export from nucleus →	+0.101	+0.856	<.001	<.001	3	14
OVARY	Protein acetylation →	+0.119	+0.869	<.001	<.001	3	14
BLOOD_Myeloma	Protein deubiquitination →	+0.059	+0.926	<.001	.001	3	13
SOFT_TISSUE	Positive regulation of mRNA processing →	+0.152	+0.783	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,987 associations by consensus.

Protein K11-linked ubiquitination by POLR2B expression — OVARY

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