POLR2B

Across TCGA cell cohorts, POLR2B mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR2B-associated genes across cancer lineages are F9, CELA3A, and MRAP. Each is linked with POLR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2B-to-partner and partner-to-POLR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by POLR2B-low versus POLR2B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2B→partner) and Y-score (partner→POLR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	F9 →	+0.004	+4.196	<.001	.006	3	1
BREAST	CELA3A →	+0.125	+4.196	<.001	.006	3	1
BREAST	MRAP →	+0.056	+3.672	<.001	.006	3	1
BLOOD_Leukemia	OR5P3 →	+0.111	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM47A →	+0.041	+4.922	<.001	.009	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

F9 by POLR2B expression — BREAST

Explore this box plot interactively →