POLR1H

Across TCGA pan-cancer cohorts, POLR1H Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POLR1H data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher POLR1H Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POLR1H expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, UCEC, and SKCM are the cancer types where POLR1H Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
UCEC	DFS	Median	All	1.000	0.631	.033	8	view →
SKCM	OS	Median	All	0.455	0.783	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

POLR1H–LIHC (OS)

Open the LIHC breakdown →