POLR1H

Across TCGA pan-cancer cohorts, POLR1H mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR1H data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLR1H mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR1H expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where POLR1H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.295	0.851	<.001	53	view →
LSCC	DFS	Tertile	II,III,IV	0.921	0.577	.008	16	view →
HNSC	DFS	Tertile	IV	0.605	0.903	.020	9	view →
GBM	OS	Median	All	0.748	0.966	.012	3	view →
UCEC	DFS	Median	All	1.000	0.936	.022	2	view →
PDAC	DFS	Tertile	All	0.241	0.661	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR1H–CCRCC (DFS)

Open the CCRCC breakdown →