POLR1F

Across TCGA pan-cancer cohorts, POLR1F mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of POLR1F’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where POLR1F mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR1F is over-expressed in tumor.

LSCC, LUAD, and HNSC are the cancer types where POLR1F tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR1F mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.697	<.001	8	view →
LUAD	Male	III,IV	+0.697	<.001	8	view →
HNSC	Male	III,IV	+0.286	<.001	8	view →
COAD	Male	All	+0.427	<.001	6	view →
PDAC	Male	All	+0.294	.002	4	view →
CCRCC	Male	All	+0.161	<.001	4	view →
OV	All	All	+0.723	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

POLR1F–LSCC

Open the LSCC breakdown →