POLR1C

Across TCGA pan-cancer cohorts, POLR1C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR1C data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher POLR1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated POLR1C expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where POLR1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.955	0.699	.003	28	view →
LUAD	OS	Median	III,IV	0.879	0.285	.001	24	view →
HNSC	OS	Median	IV	0.741	0.925	.011	20	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.273	.049	4	view →
GBM	OS	Tertile	All	0.488	0.249	.009	4	view →
PDAC	OS	Tertile	III,IV	0.774	0.369	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR1C–LSCC (OS)

Open the LSCC breakdown →