POLR1C

Across TCGA patient cohorts, POLR1C mutation is significantly associated with the RNA expression of many other genes, with 1,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1C-associated genes across cancer lineages are NDUFA5P5, OR11H5P, and RN7SL42P. Each is linked with POLR1C in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1C-to-partner and partner-to-POLR1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P5 grouped by POLR1C-low versus POLR1C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1C→partner) and Y-score (partner→POLR1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NDUFA5P5 →	+0.155	+6.866	<.001	<.001	3	2
CESC	OR11H5P →	+0.030	+5.144	<.001	.003	3	2
CESC	RN7SL42P →	+0.139	+5.342	<.001	.002	3	2
CESC	ELMO2P1 →	+0.042	+4.364	.007	.006	3	2
BRCA	RANP9 →	+0.262	+7.038	<.001	<.001	3	2
BRCA	MTND1P6 →	+0.081	+5.800	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,187 associations by consensus.

NDUFA5P5 by POLR1C expression — BRCA

Explore this box plot interactively →