POLR1C

Across TCGA patient cohorts, POLR1C mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1C-associated genes across cancer lineages are Stathmin, ATM, and E-Cadherin. Each is linked with POLR1C in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1C-to-partner and partner-to-POLR1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by POLR1C-low versus POLR1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1C→partner) and Y-score (partner→POLR1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.169	+2.321	.008	.034	3	2
UCEC	ATM →	-0.728	-3.156	<.001	.018	3	2
UCEC	E-Cadherin →	-0.573	-2.990	.011	.036	3	2
UCEC	EGFR_pY1068 →	-0.304	-2.584	.009	.011	2	2
UCEC	Myosin-IIa_pS1943 →	+0.244	+1.887	.011	.031	3	1
UCEC	Myosin-IIa →	+0.222	+3.010	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Stathmin by POLR1C expression — UCEC

Explore this box plot interactively →