POLR1C

Across TCGA cell cohorts, POLR1C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,228 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POLR1C-associated GO terms across cancer lineages are Maturation of 5.8S rRNA, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with POLR1C in more than 15 cancer types. Because this analysis shows association rather than direction, both POLR1C-to-partner and partner-to-POLR1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA grouped by POLR1C-low versus POLR1C-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1C→partner) and Y-score (partner→POLR1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of 5.8S rRNA →	+0.124	+0.571	<.001	<.001	3	16
BLOOD_Lymphoma	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.112	+0.802	<.001	<.001	3	16
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.111	+0.603	<.001	<.001	3	16
BONE	Maturation of LSU-rRNA →	+0.153	+0.669	<.001	<.001	3	16
BONE	rRNA metabolic process →	+0.156	+1.057	<.001	<.001	3	16
BONE	Maturation of SSU-rRNA →	+0.150	+0.883	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,228 associations by consensus.

Maturation of 5.8S rRNA by POLR1C expression — BONE

Explore this box plot interactively →