POLR1B

Across TCGA cell cohorts, POLR1B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,123 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible POLR1B-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Termination of RNA polymerase I transcription, and Transcription by RNA polymerase I. Each is linked with POLR1B in more than 19 cancer types. Because this analysis shows association rather than direction, both POLR1B-to-partner and partner-to-POLR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by POLR1B-low versus POLR1B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1B→partner) and Y-score (partner→POLR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Transcription initiation at RNA polymerase I promoter →	+0.155	+1.162	<.001	<.001	3	20
URINARY_TRACT	Termination of RNA polymerase I transcription →	+0.134	+1.044	<.001	<.001	3	20
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.119	+0.818	<.001	<.001	3	19
LUNG_SCLC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.171	+0.840	<.001	<.001	3	19
BLOOD_Myeloma	Ribosome biogenesis →	+0.122	+1.013	<.001	<.001	3	19
BONE	rRNA transcription →	+0.141	+1.029	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,123 associations by consensus.

Transcription initiation at RNA polymerase I promoter by POLR1B expression — LUNG_NSCLC_LUSC

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