POLM

Across TCGA pan-cancer cohorts, POLM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLM data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLM expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, LSCC, and GBM are the cancer types where POLM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.799	0.998	.001	19	view →
LSCC	OS	Quartile	All	0.692	0.926	.026	8	view →
GBM	DFS	Tertile	All	0.379	0.700	.017	6	view →
CCRCC	DFS	Quartile	All	1.000	0.574	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLM–LUAD (DFS)

Open the LUAD breakdown →