POLM

Across TCGA patient cohorts, POLM protein abundance is significantly associated with the RNA expression of many other genes, with 3,333 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible POLM-associated genes across cancer lineages are FNDC4, COMP, and ARHGAP23. Each is linked with POLM in more than 2 cancer types. Because this analysis shows association rather than direction, both POLM-to-partner and partner-to-POLM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLM versus FNDC4 in CCRCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLM→partner) and Y-score (partner→POLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FNDC4 →	+1.702	+0.516	<.001	.009	3	3
CCRCC	COMP →	+2.175	+0.708	<.001	<.001	3	3
OV	ARHGAP23 →	+1.241	+0.597	<.001	<.001	3	3
CCRCC	LTBP2 →	+1.327	+0.477	.001	<.001	3	3
CCRCC	TPM2 →	+1.583	+0.583	<.001	<.001	3	3
UCEC	BMERB1 →	+0.874	+0.352	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,333 associations by consensus.

POLM vs FNDC4 — CCRCC

Explore this scatter interactively →