POLM

Across TCGA patient cohorts, POLM mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLM-associated genes across cancer lineages are Rad50, Cyclin-B1, and eIF4E. Each is linked with POLM in more than 1 cancer types. Because this analysis shows association rather than direction, both POLM-to-partner and partner-to-POLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by POLM-low versus POLM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLM→partner) and Y-score (partner→POLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.213	-1.765	.019	.014	3	2
UCEC	Cyclin-B1 →	+0.483	+2.115	.021	.017	3	2
UCEC	eIF4E →	+0.198	+3.472	.012	.002	3	1
UCEC	A-Raf_pS299 →	-0.097	-2.321	.030	.034	3	1
UCEC	Ku80 →	+0.189	+1.428	.032	.029	3	1
UCEC	MEK1 →	+0.341	+3.584	.013	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by POLM expression — UCEC

Explore this box plot interactively →