POLM

Across TCGA cell cohorts, POLM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,938 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLM-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with POLM in more than 13 cancer types. Because this analysis shows association rather than direction, both POLM-to-partner and partner-to-POLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by POLM-low versus POLM-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLM→partner) and Y-score (partner→POLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.154	+1.180	<.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.104	-1.064	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.104	-1.064	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.111	-1.100	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.107	-1.064	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.111	-1.100	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,938 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by POLM expression — OESOPHAGUS

Explore this box plot interactively →