POLM

Across TCGA cell cohorts, POLM mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLM-associated genes across cancer lineages are I-BET-151, Doxorubicin, and Pevonedistat. Each is linked with POLM in more than 1 cancer types. Because this analysis shows association rather than direction, both POLM-to-partner and partner-to-POLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, I-BET-151 grouped by POLM-low versus POLM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLM→partner) and Y-score (partner→POLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	I-BET-151 →	+0.635	+2.777	.002	.038	3	1
LARGE_INTESTINE	Doxorubicin →	+0.702	+2.649	.008	.046	2	2
LARGE_INTESTINE	Pevonedistat →	+0.965	+2.649	.004	.046	3	1
LARGE_INTESTINE	BPD-00008900 →	+0.400	+2.655	.047	.044	3	1
LARGE_INTESTINE	GSK1070916 →	+0.950	+2.722	<.001	.023	3	1
LARGE_INTESTINE	CUDC-101 →	+0.609	+2.874	.006	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

I-BET-151 by POLM expression — LARGE_INTESTINE

Explore this box plot interactively →