POLL

Across TCGA pan-cancer cohorts, POLL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLL data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where POLL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.315	0.975	.006	18	view →
PDAC	OS	Quartile	All	0.308	0.756	.012	18	view →
LUAD	DFS	Tertile	All	0.343	0.716	.003	16	view →
GBM	OS	Median	All	0.418	0.623	.022	2	view →
UCEC	OS	Tertile	All	0.969	0.834	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLL–HNSC (DFS)

Open the HNSC breakdown →