POLK

Across TCGA pan-cancer cohorts, POLK mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of POLK’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where POLK mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POLK is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, CCRCC, and HNSC are the cancer types where POLK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	−0.187	<.001	8	view →
CCRCC	Male	All	+0.240	<.001	7	view →
HNSC	All	III,IV	−0.347	.005	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

POLK–LSCC

Open the LSCC breakdown →