POLK

Across TCGA patient cohorts, POLK mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLK-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with POLK in more than 1 cancer types. Because this analysis shows association rather than direction, both POLK-to-partner and partner-to-POLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by POLK-low versus POLK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLK→partner) and Y-score (partner→POLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.087	-2.195	.008	.009	3	2
UCEC	EGFR_pY1068 →	-0.247	-1.652	.002	.006	3	2
UCEC	eIF4E →	+0.223	+3.713	.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.088	-1.492	.033	.027	3	2
UCEC	INPP4B →	-0.241	-2.222	.024	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.217	-3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

14-3-3_beta by POLK expression — UCEC

Explore this box plot interactively →