POLK

Across TCGA cell cohorts, POLK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,588 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLK-associated GO terms across cancer lineages are Translesion synthesis, DNA damage tolerance, and Nucleotide-excision repair, DNA gap filling. Each is linked with POLK in more than 15 cancer types. Because this analysis shows association rather than direction, both POLK-to-partner and partner-to-POLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translesion synthesis grouped by POLK-low versus POLK-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLK→partner) and Y-score (partner→POLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Translesion synthesis →	+0.085	+1.144	.001	<.001	3	16
PANCREAS	DNA damage tolerance →	+0.089	+0.676	<.001	<.001	3	16
URINARY_TRACT	Nucleotide-excision repair, DNA gap filling →	+0.099	+0.982	<.001	<.001	3	16
URINARY_TRACT	DNA synthesis involved in DNA replication →	+0.084	+1.041	.001	<.001	3	15
KIDNEY	Target-directed miRNA degradation →	+0.122	+0.804	<.001	.001	3	15
URINARY_TRACT	DNA biosynthetic process →	+0.083	+1.052	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,588 associations by consensus.

Translesion synthesis by POLK expression — URINARY_TRACT

Explore this box plot interactively →