POLK

Across TCGA cell cohorts, POLK mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLK-associated genes across cancer lineages are TAFA1, KRTAP5-6, and APLNR. Each is linked with POLK in more than 1 cancer types. Because this analysis shows association rather than direction, both POLK-to-partner and partner-to-POLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by POLK-low versus POLK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLK→partner) and Y-score (partner→POLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	2
LARGE_INTESTINE	KRTAP5-6 →	+0.382	+3.736	<.001	.002	3	2
LARGE_INTESTINE	APLNR →	+0.251	+3.799	<.001	.003	3	1
LARGE_INTESTINE	CPO →	+0.099	+3.514	.009	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	OR5AK2 →	+0.034	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TAFA1 by POLK expression — LARGE_INTESTINE

Explore this box plot interactively →