POLI

Across TCGA pan-cancer cohorts, POLI mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLI data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher POLI mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLI expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

GBM, COAD, and CCRCC are the cancer types where POLI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.237	0.498	.006	24	view →
COAD	DFS	Tertile	III,IV	0.828	1.000	.045	18	view →
CCRCC	DFS	Quartile	III,IV	0.619	0.238	.005	8	view →
LUAD	OS	Median	III,IV	1.000	0.770	.006	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
LSCC	DFS	Tertile	II,III,IV	0.885	1.000	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLI–GBM (DFS)

Open the GBM breakdown →