POLI

Across TCGA patient cohorts, POLI protein abundance is significantly associated with the RNA expression of many other genes, with 18,426 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLI-associated genes across cancer lineages are ZNF704, PIGH, and ZC3H14. Each is linked with POLI in more than 5 cancer types. Because this analysis shows association rather than direction, both POLI-to-partner and partner-to-POLI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLI versus ZNF704 in CCRCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLI→partner) and Y-score (partner→POLI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF704 →	+0.886	+0.303	<.001	<.001	3	6
BRCA	PIGH →	+0.635	+0.377	<.001	<.001	3	4
COAD	ZC3H14 →	+0.885	+0.464	.002	.003	2	5
COAD	ZNF45 →	+0.556	+0.544	.001	.005	3	4
BRCA	RBFA →	+0.501	+0.435	<.001	<.001	3	4
LSCC	NCF2 →	-0.622	-0.274	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,426 associations by consensus.

POLI vs ZNF704 — CCRCC

Explore this scatter interactively →