POLI

Across TCGA cell cohorts, POLI RNA expression is significantly associated with the go_rna of many other GO terms, with 3,594 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible POLI-associated GO terms across cancer lineages are Peptidyl-lysine acetylation, Protein localization to cytoplasmic stress granule, and Non-motile cilium assembly. Each is linked with POLI in more than 11 cancer types. Because this analysis shows association rather than direction, both POLI-to-partner and partner-to-POLI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine acetylation grouped by POLI-low versus POLI-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLI→partner) and Y-score (partner→POLI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Peptidyl-lysine acetylation →	+0.119	+0.751	.001	.006	2	12
LUNG_SCLC	Protein localization to cytoplasmic stress granule →	+0.153	+0.943	<.001	<.001	3	11
KIDNEY	Non-motile cilium assembly →	+0.066	+0.967	<.001	.001	3	11
SOFT_TISSUE	Error-prone translesion synthesis →	+0.098	+1.054	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.125	+1.120	.001	.001	3	10
LUNG_SCLC	DNA biosynthetic process →	+0.076	+1.056	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,594 associations by consensus.

Peptidyl-lysine acetylation by POLI expression — BONE

Explore this box plot interactively →