POLI

Across TCGA cell cohorts, POLI mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLI-associated genes across cancer lineages are OR6J1, PPP1R2C, and IFNG. Each is linked with POLI in more than 1 cancer types. Because this analysis shows association rather than direction, both POLI-to-partner and partner-to-POLI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6J1 grouped by POLI-low versus POLI-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLI→partner) and Y-score (partner→POLI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6J1 →	+0.004	+4.643	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	PPP1R2C →	+0.025	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IFNG →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TSPY8 →	+0.023	+5.357	<.001	.003	3	1
LARGE_INTESTINE	TOMM22 →	+0.604	+3.364	<.001	.002	3	1
LARGE_INTESTINE	JOSD1 →	+0.561	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

OR6J1 by POLI expression — BLOOD_Lymphoma

Explore this box plot interactively →