POLHP1

Across TCGA pan-cancer cohorts, POLHP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLHP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLHP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLHP1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, UCEC, and BRCA are the cancer types where POLHP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLHP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.069	.029	7	view →
UCEC	All	IV	+0.300	.037	2	view →
BRCA	Female	All	+0.162	.042	2	view →
KICH	Female	All	−0.120	.047	2	view →
THCA	Female	All	−0.092	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLHP1–HNSC

Open the HNSC breakdown →