POLH

Across TCGA patient cohorts, POLH protein abundance is significantly associated with the RNA expression of many other genes, with 1,871 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POLH-associated genes across cancer lineages are PCDHB15, BMERB1, and FAXDC2. Each is linked with POLH in more than 1 cancer types. Because this analysis shows association rather than direction, both POLH-to-partner and partner-to-POLH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLH versus PCDHB15 in GBM, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH→partner) and Y-score (partner→POLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCDHB15 →	-0.981	-0.604	.001	.003	3	2
BRCA	BMERB1 →	-1.283	-0.425	.001	.001	3	2
BRCA	FAXDC2 →	-1.219	-0.341	.007	.009	3	2
UCEC	MIR4714 →	-2.218	-0.459	.004	.001	3	2
GBM	ZNF728 →	-0.608	-0.554	.003	.005	3	2
BRCA	REEP6 →	-2.055	-0.372	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,871 associations by consensus.

POLH vs PCDHB15 — GBM

Explore this scatter interactively →