POLH

Across TCGA patient cohorts, POLH mutation is significantly associated with the RNA expression of many other genes, with 1,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLH-associated genes across cancer lineages are BOLA3P1, PEBP1P1, and BNIP3P3. Each is linked with POLH in more than 1 cancer types. Because this analysis shows association rather than direction, both POLH-to-partner and partner-to-POLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BOLA3P1 grouped by POLH-low versus POLH-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH→partner) and Y-score (partner→POLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	BOLA3P1 →	+0.171	+4.057	<.001	.001	3	2
BLCA	PEBP1P1 →	+0.094	+4.057	<.001	.001	3	2
BLCA	BNIP3P3 →	+0.053	+4.618	<.001	.005	3	2
BLCA	RN7SL478P →	+0.376	+5.005	<.001	<.001	3	2
CESC	RNU1-62P →	+0.261	+5.539	<.001	.004	3	2
CESC	RNU6-777P →	+0.477	+5.539	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,598 associations by consensus.

BOLA3P1 by POLH expression — BLCA

Explore this box plot interactively →