POLH

Across TCGA patient cohorts, POLH mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLH-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and eEF2. Each is linked with POLH in more than 1 cancer types. Because this analysis shows association rather than direction, both POLH-to-partner and partner-to-POLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by POLH-low versus POLH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH→partner) and Y-score (partner→POLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.210	+1.362	.028	.037	3	2
UCEC	14-3-3_beta →	-0.081	-2.195	.022	.009	3	1
UCEC	eEF2 →	+0.333	+2.321	.008	.033	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.700	.004	.005	3	1
UCEC	eIF4E →	+0.162	+2.000	.029	.003	3	1
UCEC	A-Raf_pS299 →	-0.141	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

4E-BP1 by POLH expression — UCEC

Explore this box plot interactively →