POLH

Across TCGA cell cohorts, POLH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,938 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLH-associated GO terms across cancer lineages are Error-free translesion synthesis, Translesion synthesis, and DNA synthesis involved in DNA replication. Each is linked with POLH in more than 17 cancer types. Because this analysis shows association rather than direction, both POLH-to-partner and partner-to-POLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Error-free translesion synthesis grouped by POLH-low versus POLH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLH→partner) and Y-score (partner→POLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Error-free translesion synthesis →	+0.168	+1.083	<.001	<.001	3	18
PANCREAS	Translesion synthesis →	+0.089	+1.428	<.001	<.001	3	18
SKIN	DNA synthesis involved in DNA replication →	+0.088	+0.898	<.001	<.001	3	17
SKIN	DNA damage tolerance →	+0.093	+0.993	<.001	<.001	3	16
OESOPHAGUS	DNA synthesis involved in DNA repair →	+0.109	+1.089	.001	<.001	3	15
BREAST	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.180	+1.089	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,938 associations by consensus.

Error-free translesion synthesis by POLH expression — BONE

Explore this box plot interactively →