POLG2

Across TCGA pan-cancer cohorts, POLG2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POLG2 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLG2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POLG2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD and UCEC are the cancer types where POLG2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.236	0.812	.003	15	view →
UCEC	DFS	Median	All	0.948	0.622	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

POLG2–LUAD (OS)

Open the LUAD breakdown →