POLG2

Across TCGA pan-cancer cohorts, POLG2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of POLG2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where POLG2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POLG2 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where POLG2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLG2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	−0.248	<.001	11	view →
LUAD	Male	II,III,IV	+0.329	<.001	6	view →
COAD	Male	II,III,IV	+0.298	.004	6	view →
PDAC	All	II,III,IV	−0.341	.008	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

POLG2–CCRCC

Open the CCRCC breakdown →