POLG2

Across TCGA patient cohorts, POLG2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,764 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLG2-associated genes across cancer lineages are TYROBP, SASH3, and GPR65. Each is linked with POLG2 in more than 4 cancer types. Because this analysis shows association rather than direction, both POLG2-to-partner and partner-to-POLG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLG2 versus TYROBP in GBM, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG2→partner) and Y-score (partner→POLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TYROBP →	-0.943	-0.380	<.001	<.001	3	5
GBM	SASH3 →	-1.005	-0.376	<.001	<.001	3	5
GBM	GPR65 →	-0.946	-0.416	<.001	<.001	3	5
OV	FCGR2A →	-0.669	-0.244	.002	.007	3	5
OV	FCER1G →	-0.926	-0.395	.001	<.001	3	5
BRCA	HTRA1 →	-0.904	-0.269	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,764 associations by consensus.

POLG2 vs TYROBP — GBM

Explore this scatter interactively →