POLG2

Across TCGA patient cohorts, POLG2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLG2-associated genes across cancer lineages are eEF2, MEK1, and Ku80. Each is linked with POLG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLG2-to-partner and partner-to-POLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by POLG2-low versus POLG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG2→partner) and Y-score (partner→POLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.383	+2.321	.033	.035	3	2
UCEC	MEK1 →	+0.409	+3.321	.026	.010	3	2
UCEC	Ku80 →	+0.241	+2.335	.042	.020	3	1
UCEC	Notch1 →	+0.189	+3.009	.007	.019	3	1
UCEC	p70-S6K →	+0.234	+3.486	.015	.002	3	1
UCEC	PDCD4 →	-0.631	-3.459	.007	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by POLG2 expression — UCEC

Explore this box plot interactively →