POLG2

Across TCGA cell cohorts, POLG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,729 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLG2-associated GO terms across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Subtelomeric heterochromatin formation, and Telomere organization. Each is linked with POLG2 in more than 15 cancer types. Because this analysis shows association rather than direction, both POLG2-to-partner and partner-to-POLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by POLG2-low versus POLG2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLG2→partner) and Y-score (partner→POLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.106	+1.197	<.001	<.001	3	16
BONE	Subtelomeric heterochromatin formation →	+0.174	+1.103	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Telomere organization →	+0.095	+1.305	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere maintenance →	+0.097	+1.672	<.001	<.001	3	16
CNS	DNA biosynthetic process →	+0.070	+0.840	<.001	<.001	3	16
OESOPHAGUS	mRNA splice site recognition →	+0.117	+0.760	.008	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,729 associations by consensus.

Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by POLG2 expression — BONE

Explore this box plot interactively →