POLG

Across TCGA pan-cancer cohorts, POLG mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of POLG’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where POLG mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POLG is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where POLG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.529	<.001	7	view →
LUAD	All	All	−0.135	<.001	6	view →
HNSC	All	All	−0.109	.031	3	view →
CCRCC	Male	All	−0.092	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

POLG–PDAC

Open the PDAC breakdown →