POLE3

Across TCGA patient cohorts, POLE3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,241 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLE3-associated genes across cancer lineages are CDKN3, OIP5, and MCM4. Each is linked with POLE3 in more than 7 cancer types. Because this analysis shows association rather than direction, both POLE3-to-partner and partner-to-POLE3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLE3 versus CDKN3 in OV, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE3→partner) and Y-score (partner→POLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDKN3 →	+1.398	+0.635	<.001	<.001	3	8
OV	OIP5 →	+0.905	+0.615	<.001	<.001	3	8
BRCA	MCM4 →	+0.992	+0.447	<.001	<.001	3	8
LSCC	RAD51AP1 →	+1.202	+0.460	<.001	<.001	3	8
UCEC	TTK →	+1.123	+0.312	<.001	<.001	3	8
UCEC	ECT2 →	+0.796	+0.421	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,241 associations by consensus.

POLE3 vs CDKN3 — OV

Explore this scatter interactively →